eOphthalmology Review
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    eOphthalmology Review Volume 3 Issue 5
NIH-sponsored Diabetic Retinopathy Clinical Research Network's comparative effectiveness trial findings on aflibercept, bevacizumab, and ranibizumab for DME treatment
After participating in this activity, the participant will demonstrate the ability to:

Describe the design and visual acuity outcomes when comparing aflibercept, bevacizumab and ranibizumab for diabetic macular edema.
Discuss the OCT outcomes in the first year of this comparative effectiveness trial, and how these treatments were applied.
Explain the safety findings in the first year of this comparative effectiveness trial.

This discussion, offered as a downloadable audio file and companion transcript, covers the important CER findings on aflibercept, bevacizumab, and ranibizumab for DME treatment as reported from the Macula Society meeting in Scottsdale, Arizona. The format for this round-table discussion is case-study scenarios for the clinical practice.


Unlabeled/Unapproved Uses

Our faculty have disclosed that there will be off-label discussion of bevacizumab.
Dr. Neil M. Bressler Neil M. Bressler, MD
The James P. Gills Professor of Ophthalmology
Chief, Retina Division
Wilmer Eye Institute
Johns Hopkins University School of Medicine
Baltimore, Maryland
Michael Elman, MD Michael Elman, MD
Assistant Professor
Johns Hopkins University
Baltimore, Maryland
John Wells, MD John Wells, MD
Palmetto Retina Center
Columbia, South Carolina

Faculty Disclosures

Dr. Neil Bressler has disclosed that, in the past year, he has served as a principal investigator of research projects at the Johns Hopkins University sponsored by Bayer, Genentech, Novartis, and Regeneron.

Dr. Michael Elman has disclosed that he has received grants from Genentech, Merck, Notal, and Ohr Pharmaceutical. He has served as a consultant for Genentech and Notal. In addition, he has ownership interest in Ohr Pharmaceutical. He has also received lecture honoraria from Genentech.

Dr. John Wells has disclosed that he has received grant and research funding from Genentech, Regeneron, Allergan, Ampio, Iconic, Kalvista, LPath Incorporated, and Ophthotech. He has served as a consultant for Alcon, PanOptica, and Iconic.
Release Date
April 7, 2015
Expiration Date
April 6, 2017
Neil M. Bressler, MD
The James P. Gills Professor of Ophthalmology
Johns Hopkins University School of Medicine
Chief, Retina Division
Wilmer Eye Institute
Baltimore, Maryland
Susan B. Bressler, MD
Julia G. Levy, PhD Professor of Ophthalmology
Retina Division
Wilmer Eye Institute
Johns Hopkins University School of Medicine
Baltimore, Maryland
 accreditation statement
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

credit designations
Physicians: The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 2.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Each podcast is certified for 0.5 credits.

successful completion
To take the post-test for eOphthalmology Review you will need to visit the Johns Hopkins University School of Medicine's website. If you have already registered for other Hopkins CME programs at this site, simply enter the requested information when prompted. Otherwise, complete the registration form to begin the testing process. A passing grade of 70% or higher on the post-test/evaluation is required to receive CME credit.


launch date
June 19, 2014; activities expire 2 years from the date of publication. Estimated time to complete activity: 30 minutes
There are no fees or prerequisites for this activity.


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disclaimer statement
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of the Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

statement of responsibility
The Johns Hopkins University School of Medicine take responsibility for the content, quality and scientific integrity of this CME activity.


STATEMENT OF NEED:
  • Clinicians lack confidence that their knowledge of new AMD developments will allow them to provide optimal patient care.
  • Clinicians are unprepared to integrate new diabetic retinopathy and diabetic macular edema research findings into their current treatment paradigms.
  • On-going research into retinal vein occlusion treatments has created clinician uncertainty about choosing the most appropriate therapeutic options.
  • Clinicians require additional knowledge about new therapies to develop best practices in treating vitreomacular abnormalities.

  • intended audience
    The activity has been developed for ophthalmologists and retina specialists.

    PLANNER disclosures
    As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. The following relationships have been reported for this activity:

    Dr. Neil Bressler, MD has disclosed that, in the past year, he has served as a principal investigator of research projects at the Johns Hopkins University sponsored by Bayer, Genentech, Novartis, and Regeneron.
    Dr. Susan Bressler, MD has disclosed that in the past year she has been an investigator in research at the Johns Hopkins University School of Medicine sponsored by Allergan USA Inc, Bausch and Lomb, Bayer Healthcare Pharmaceuticals, Lumenis, Inc, Notal Vision Ltd., Novartis Pharmaceuticals Inc, Regeneron Pharmaceuticals, Sanofi-Aventis Group, ThromboGenics NV, Boehringer Ingelheim Pharma, and has consulted for GlaxoSmithKline.
    Guest Author Disclosures

    CONFIDENTIALITY DISCLAIMER FOR CME CONFERENCE ATTENDEES

    I certify that I am attending a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

    I understand that while I am attending in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the "Privacy Regulations"). Protected health information is information about a person's health or treatment that identifies the person.

    I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (e.g. Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device.

    I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.

    "The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only."

    For CME Questions, please contact the CME Office (410) 955-2959 or e-mail cmenet@jhmi.edu. For CME Certificates, please call (410) 502-9634.

    Johns Hopkins University School of Medicine Office of Continuing Medical Education
    Turner 20/720 Rutland Avenue
    Baltimore, Maryland 21205-2195

    Reviewed & Approved by:
    General Counsel, Johns Hopkins Medicine (4/1/03)
    (Updated 4/09 and 3/14)


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